Publications

Selected publications

Dissecting the dynamics of coordinated active transcriptional repression in a multicellular organism

Virginia Pimmett, Maria Douaihy, Louise Maillard, Antonio Trullo, Ovidiu Radulescu# and Mounia Lagha# (2024)

Biorxiv • 2024

Transcription: A hub of activity

Virginia L Pimmett, Mounia Lagha

eLife • 2023

The control of transcriptional memory by stable mitotic bookmarking

Maëlle Bellec1, Jérémy Dufourt1, George Hunt2, Hélène Lenden-Hasse1, Antonio Trullo1, Amal Zine El Aabidine1, Marie Lamarque1, Marissa M Gaskill3, Heloïse Faure-Gautron1, Mattias Mannervik2, Melissa M Harrison3, Jean-Christophe Andrau1, Cyril Favard4, Ovidiu Radulescu5, and Mounia Lagha1#.

Nature Communications • 2022 • doi.org/10.1038/s41467-022-28855-y

Un marque-page au service de la mémoire mitotique pendant le développement

Bellec et al

Site INSB_CNRS • 2022

The control of transcriptional memory by stable mitotic bookmarking

Maëlle Bellec, Jérémy Dufourt, George Hunt, Hélène Lenden-Hasse, Antonio Trullo, Amal Zine El Aabidine, Marie Lamarque, Marissa M Gaskill, Heloïse Faure-Gautron, Mattias Mannervik, Melissa M Harrison, Jean-Christophe Andrau, Cyril Favard, Ovidiu Radulescu, Mounia Lagha

bioRxiv • 2021

Le bruit des cellules : un mécanisme, deux modèles

Mounia Lagha, Edouard Bertrand et Ovidiu Radulescu

INSB • 2021

Imaging translation dynamics in live embryos reveals spatial heterogeneities

Dufourt J, Bellec M, Trullo A, Dejean M, De Rossi S, Favard C, Lagha M.

Science • 2021

Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics.

Virginia L Pimmett, Matthieu Dejean, Carola Fernandez, Antonio Trullo, Edouard Bertrand, Ovidiu Radulescu, Mounia Lagha

Nature Communications • 2021

Cis-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during early Drosophila development

Espinola SM, Götz M, Bellec M, Messina O, Fiche JB, Houbron C, Dejean M, Reim I, Cardozo Gizzi AM, Lagha M, Nollmann M.

Nat Genet. • 2021

Lightening up gene activation in living Drosophila embryos

Fernandez C and Lagha M

Methods Mol Biol • 2019

MitoTrack, a user-friendly semi-automatic software for lineage tracking in living embryos

Trullo A, Dufourt J and Lagha M

Bioinformatics • 2019

Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs

Jeremy Dufourt , Antonio Trullo, Jennifer Hunter, Carola Fernandez, Jorge Lazaro, Matthieu Dejean, Lucas Morales, Saida Nait-Amer, Katharine N. Schulz , Melissa M. Harrison, Cyril Favard , Ovidiu Radulescu & Mounia Lagha

Nature Communications • 2018

A Growing Toolbox to Image Gene Expression in Single Cells: Sensitive Approaches for Demanding Challenges

Xavier Pichon, Mounia Lagha, Florian Mueller and Edouard Bertrand

Molecular Cell • 2018 • Aug 2;71(3):468-480

Transcriptional memory in the Drosophila embryo

Ferraro T., Esposito E., Mancini L., Ng S., Lucas T., Coppey M., Dostatni N., Walczak A., Levine M. and Lagha M.

Current Biology • 2016 • Jan 25;26(2):212-8

Paused Pol II coordinates tissue morphogenesis in the Drosophila embryo

Lagha M., Bothma J., Esposito E., Samuel Ng., Stefanik L., Tsui C., Johnston J., Chen K., Gilmour D., Zeitlinger J. and Levine M.

Cell • 2013 • 153(5) 976-87

Mechanisms of transcriptional precision in development

Lagha M., Bothma J. and Levine M.

Trends in Genetics • 2012 • (8)409-16

Complete list of publications

Dissecting the dynamics of coordinated active transcriptional repression in a multicellular organism

Virginia Pimmett, Maria Douaihy, Louise Maillard, Antonio Trullo, Ovidiu Radulescu# and Mounia Lagha# (2024)

Biorxiv • 2024

Transcription: A hub of activity

Virginia L Pimmett, Mounia Lagha

eLife • 2023

The control of transcriptional memory by stable mitotic bookmarking

Nature Communications • 2022 • doi.org/10.1038/s41467-022-28855-y

Un marque-page au service de la mémoire mitotique pendant le développement

Bellec et al

Site INSB_CNRS • 2022

Silence, moteur… action ! Lumière sur la traduction des ARN messagers dans un embryon

Dufourt J, Bellec M, Trullo A, Dejean M, De Rossi S, Favard C, Lagha M.

INSB, CNRS • 2021

The control of transcriptional memory by stable mitotic bookmarking

bioRxiv • 2021

Le bruit des cellules : un mécanisme, deux modèles

Mounia Lagha, Edouard Bertrand et Ovidiu Radulescu

INSB • 2021

Imaging translation dynamics in live embryos reveals spatial heterogeneities

Dufourt J, Bellec M, Trullo A, Dejean M, De Rossi S, Favard C, Lagha M.

Science • 2021

Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics.

Virginia L Pimmett, Matthieu Dejean, Carola Fernandez, Antonio Trullo, Edouard Bertrand, Ovidiu Radulescu, Mounia Lagha

Nature Communications • 2021

Tyramine induces dynamic RNP granule remodeling and translation activation in the Drosophila brain

Nadia Formicola, Marjorie Heim, Jérémy Dufourt, Anne-Sophie Lancelot, Akira Nakamura, Mounia Lagha, Florence Besse

eLife • 2021

Cis-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during early Drosophila development

Espinola SM, Götz M, Bellec M, Messina O, Fiche JB, Houbron C, Dejean M, Reim I, Cardozo Gizzi AM, Lagha M, Nollmann M.

Nat Genet. • 2021

Lightening up gene activation in living Drosophila embryos

Fernandez C and Lagha M

Methods Mol Biol • 2019

MitoTrack, a user-friendly semi-automatic software for lineage tracking in living embryos

Trullo A, Dufourt J and Lagha M

Bioinformatics • 2019

Microscopy-based chromosome conformation capture enables simultaneous visualization of genome organization and transcription in intact organisms

Andrés M. Cardozo Gizzi1,✢, Diego I. Cattoni1, Jean-Bernard Fiche1, Sergio Espinola1, Julian Gurgo1, Olivier Messina1, Christophe Houbron1, Yuki Ogiyama2, Giorgio-Lucio Papadopoulos2, Giacomo Cavalli2, Mounia Lagha3, Marcelo Nollmann 1,#

Molecular Cell • 2019

Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs

Nature Communications • 2018

A Growing Toolbox to Image Gene Expression in Single Cells: Sensitive Approaches for Demanding Challenges

Xavier Pichon, Mounia Lagha, Florian Mueller and Edouard Bertrand

Molecular Cell • 2018 • Aug 2;71(3):468-480

Remembering the past: mitotic bookmarking in a developing embryo

Maelle Bellec, Ovidiu Radulescu and Mounia Lagha

Current Opinion in Systems Biology • 2018 • 2018, 11:41–49

Transcriptional memory in the Drosophila embryo

Ferraro T., Esposito E., Mancini L., Ng S., Lucas T., Coppey M., Dostatni N., Walczak A., Levine M. and Lagha M.

Current Biology • 2016 • Jan 25;26(2):212-8

Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium

Jang I., Lu Y., Zhao L., Wenzel P., Kume T., Datta S., Arora N., Guiu J., Lagha M., Kim P., Do E., Kim J., Schlaeger T., Zon L., Bigas A., Burns C., Daley G.

Blood • 2015 • (04)-568170

Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb

Mayeuf-Louchart A., Lagha M., Danckaert A., Rocancourt D., Relaix F., Vincent S.D., Buckingham M.

Proc Natl Acad Sci USA • 2014 • Jun 17;111(24):8844-9

Itm2a is a Pax3 target gene, expressed at sites of skeletal muscle formation in vivo

Lagha M., Chang T., Mayeuf A., Montarras D., Rocancourt D., Kormish J., Zaret K., Buckingham M. and Relaix F.

Plos One • 2013 • (5):e63143

Paused Pol II coordinates tissue morphogenesis in the Drosophila embryo

Lagha M., Bothma J., Esposito E., Samuel Ng., Stefanik L., Tsui C., Johnston J., Chen K., Gilmour D., Zeitlinger J. and Levine M.

Cell • 2013 • 153(5) 976-87

Six homeoproteins directly activate myod expression in the gene regulatory networks that control early myogenesis

Relaix F., Demignon J., Laclef C., Pujol J., Santolini M., Niro C., Lagha M., Rocancourt D., Buckingham M., Maire P.

Plos Genetics • 2013 • (4):e1003425

Mechanisms of transcriptional precision in development

Lagha M., Bothma J. and Levine M.

Trends in Genetics • 2012 • (8)409-16

Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo

Lagha M., Sato T., Regnault B., Cumano A., Zuniga A., Licht J., Relaix F. and Buckingham M.

BMC Genomics • 2010 • 11:696

Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors

Lagha M., Brunelli S., Messina G., Cumano A., Kume T., Relaix F. and Buckingham M.

Dev Cell • 2009 • 17(6):892-9

Regulation of Skeletal Muscle Stem Cell Behavior by Pax3 and Pax7

Lagha M., Sato T., Bajard L., Daubas P., Esner M., Montarras D., Relaix F., Buckingham M.

Cold Spring Harb Symp Quant Biol • 2008 • Vol. LXXIII, 73:307-15

Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program

Lagha M., Kormish J., Rocancourt D., Manceau M., Epstein JA., Zaret KS., Relaix F. and Buckingham M.

Genes Dev • 2008 • 22:1828-37

A novel genetic hierarchy functions during hypaxial myogenesis : Pax3 directly activates Myf5 in muscle progenitor cells in the limb

Bajard L., Relaix F., Lagha M., Rocancourt D., Daubas P. and Buckingham M.

Genes Dev • 2006 • 20 :2450-64

Myogenic progenitor cells in the mouse embryo are marked by the expression of Pax3/7 genes that regulate their survival and myogenic potential

Buckingham M., Bajard L., Daubas P., Esner M., Lagha M., Relaix F., Rocancourt D.

Anat Embryol • 2006 • (Berl) 211 :51-6