PROJECT 2

Analyze the inheritance of transcriptional states from mother to daughter cells and identify the bookmarking mechanisms at play

 

Live imaging of transcription allows us to record, for the first time, the inheritance of active transcriptional states (memory) from mother to daughter cells during Drosophila embryogenesis. Here, memory is related to the kinetics of gene de novo re-activation during mitotic exit (transcriptional foci) and not to the inheritance of accumulated cytoplasmic mRNAs.

Our objective is to document the existence of transcriptional memory in the early embryo and understand the function and mechanisms regulating this phenomenon.

                    Visualization of Memory